AHRQ/Effective Health Care Program

Interventions To Improve Patient Adherence to Hepatitis C Treatment:
Comparative Effectiveness

Objectives

Patients with chronic hepatitis C often have difficulties adhering to antiviral therapy due to the complexities of treatment and the adverse events commonly experienced. This Comparative Effectiveness Review (CER) systematically assesses the comparative benefits and harms of treatment adherence interventions for adults receiving combination antiviral therapy for chronic hepatitis C.

Data sources

We searched MEDLINE®, PubMed®, CENTRAL, PsycInfo, Embase, and CINAHL from 2001 through June 20, 2012, as well as reference lists of relevant review articles. Review methods. We developed the review protocol, including the analytic framework and Key Questions, with input from Key Informants and technical experts. Two investigators independently assessed titles and abstracts for eligibility against predefined inclusion/exclusion criteria. Two investigators reviewed full-text articles and independently quality-rated those meeting inclusion criteria. One reviewer abstracted data from all included studies; these data were verified by another reviewer. We summarized data qualitatively grouped by intervention

AHRQ/Effective Health Care Program: A new report released. Interventions To Improve Patient Adherence to Hepatitis C Treatment: Comparative Effectiveness. Read the results and conclusions of the full report at http://www.effectivehealthcare.ahrq.gov/ehc/products/326/1363/CER91_HepatitisCTreatmentAdherence_FinalReport_20121213.pdf  Read Full Report